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Research

My scientific work is usually somehow related to my daily work as a neuroradiologist working in emergency radiology. I’m now mainly working with AI related projects.

If you are interested in citations to the works listed here, see my Google Scholar profile.

Publications

2024

Happonen, T., Nyman, M., Ylikotila, P., Mattila, K., & Hirvonen, J. (2024). Imaging Outcomes of Emergency MR Imaging in Dizziness and Vertigo: A Retrospective Cohort Study. AJNR. American Journal of Neuroradiology.

Sirén, A., Nyman, M., Syvänen, J., Mattila, K., & Hirvonen, J. (2024). Utility of brain imaging in pediatric patients with a suspected accidental spinal injury but no brain injury-related symptoms. Child’s Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery, 40(5), 1435–1441.

Sirén, A., Syvänen, J., Nyman, M., Mattila, K., & Hirvonen, J. (2024). Outcomes of Follow-up Imaging After Pediatric Spinal Trauma Confirmed With Magnetic Resonance Imaging. Journal of Pediatric Orthopedics.

2023

Huhtanen, J. T., Nyman, M., Sequeiros, R. B., Koskinen, S. K., Pudas, T. K., Kajander, S., Niemi, P., Löyttyniemi, E., Aronen, H. J., & Hirvonen, J. Discrepancies between Radiology Specialists and Residents in Fracture Detection from Musculoskeletal Radiographs. Diagnostics 13, no. 20 (January 2023): 3207.

Vierula, J.-P., Nurminen, J., Jussila, V., Nyman, M., Heikkinen, J., Pape, B., Sorvettula, K., Mattila, K., & Hirvonen, J. Diagnostic Performance of Short Noncontrast Biparametric 3-T MRI for Tonsillar Infections: Comparison with a Full Protocol Including Contrast-Enhanced Sequences. European Radiology Experimental 7, no. 1 (October 24, 2023): 65.

Sirén, A., Nyman, M., Syvänen, J., Mattila, K., & Hirvonen, J. (2023). Clinical outcome following magnetic resonance imaging as first-line imaging in low-impact pediatric spine trauma: a single-center retrospective observational study. Pediatric Radiology.

Nurminen, J., Heikkinen, J., Happonen, T., Nyman, M., Sirén, A., Vierula, J.-P., Velhonoja, J., Irjala, H., Soukka, T., Ivaska, L., Mattila, K., & Hirvonen, J. (2023). Pictorial Review of MRI Findings in Acute Neck Infections in Children. Children, 10(6), 967.

Hirvonen, J., & Nyman, M. (2023). Ostaisinko radiologista tekoälyä sairaalaan-mitä asiasta pitää tietää? Duodecim; Laaketieteellinen Aikakauskirja, 139(6), 421–423.

Sirén, A., Nyman, M., Syvänen, J., Mattila, K., & Hirvonen, J. (2023). Emergency MRI in spine trauma of children and adolescents-A pictorial review. Children, 10(7).

Happonen, T., Nyman, M., Ylikotila, P., Kytö, V., Laukka, D., Mattila, K., & Hirvonen, J. (2023). Imaging Outcomes of Emergency MRI in Patients with Suspected Cerebral Venous Sinus Thrombosis: A Retrospective Cohort Study. Diagnostics (Basel, Switzerland), 13(12).

Kantonen, O., Laaksonen, L., Alkire, M., Scheinin, A., Långsjö, J., Kallionpää, R. E., Kaisti, K., Radek, L., Johansson, J., Laitio, T., Maksimow, A., Scheinin, J., Nyman, M., Scheinin, M., Solin, O., Vahlberg, T., Revonsuo, A., Valli, K., & Scheinin, H. (2023). Decreased Thalamic Activity Is a Correlate for Disconnectedness During Anesthesia with Propofol, Dexmedetomidine and Sevoflurane but not S-Ketamine. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience.

Laaksonen, M., Rinne, J., Rahi, M., Posti, J. P., Laitio, R., Kivelev, J., Saarenpää, I., Laukka, D., Frösen, J., Ronkainen, A., Bendel, S., Långsjö, J., Ala-Peijari, M., Saunavaara, J., Parkkola, R., Nyman, M., Martikainen, I. K., Dickens, A. M., Rinne, J., … Laitio, T. (2023). Effect of xenon on brain injury, neurological outcome, and survival in patients after aneurysmal subarachnoid hemorrhage-study protocol for a randomized clinical trial. Trials, 24(1), 417.

Hirvonen J, Heikkinen J, Nyman M, Happonen T, Velhonoja J, Irjala H, Soukka T, Mattila K, Nurminen J. MRI of acute neck infections: evidence summary and pictorial review. Insights Imaging. 2023 Jan 8;14(1):5. doi: 10.1186/s13244-022-01347-9. PMID: 36617619; PMCID: PMC9826778.

2022

Happonen, T., Nyman, M., Ylikotila, P., Merisaari, H., Mattila, K., & Hirvonen, J. (2022). Diagnostic yield of emergency MRI in non-traumatic headache. Neuroradiology.

Heikkinen J, Jokihaka, V, Nurminen J, Jussila V, Velhonoja J, Irjala H, Soukka T, Happonen T, Järnsted J, Nyman M, Mattila K, Hirvonen J. MRI of odontogenic maxillofacial infections: diagnostic accuracy and reliability. Oral Radiology. 2022.

Huhtanen, J. T., Nyman, M., Doncenco, D., Hamedian, M., Kawalya, D., Salminen, L., Sequeiros, R. B., Koskinen, S. K., Pudas, T. K., Kajander, S., Niemi, P., Hirvonen, J., Aronen, H. J., & Jafaritadi, M. (2022). Deep learning accurately classifies elbow joint effusion in adult and pediatric radiographs. Scientific Reports, 12(1), 11803.

Pöyhönen HM, Nyman MJ, Peltola VT, Löyttyniemi ES, Lähdesmäki TT. Neuroimaging and neurological outcome of children with acute encephalitis. Dev Med Child Neurol. 2022 May 8. doi: 10.1111/dmcn.15261. Epub ahead of print. PMID: 35527347.

Huhtanen, H., Nyman, M., Mohsen, T., Virkki, A., Karlssson A., Hirvonen J. Automated detection of pulmonary embolism from CT-angiograms using deep learning. BMC Med Imaging 22, 43 (2022).

Heikkinen J., Nurminen J., Velhonoja J., Irjala H., Soukka T., Happonen T., Nyman M., Mattila K., Hirvonen J. (2022). MRI Findings in Acute Tonsillar Infections. American Journal of Neuroradiology February 2022, 43 (2) 286-291.

2021

Nurminen J., Velhonoja J., Heikkinen J., Happonen T., Nyman, M., et al. Emergency neck MRI: feasibility and diagnostic accuracy in cases of neck infection. Acta Radiologica. 2021;62(6):735-742. doi:10.1177/0284185120940242

Jussila, V., Niiniviita, H., Nyman, M., Paananen, T., Tammilehto, V., Mattila, K. (2021). Kaksoisenergiatietokonetomografia - lisärvoa päivystyskuvantamiseen? Duodecim, 2021;137(7):701-9

Scheinin, A., Kantonen, O., Alkire, M., Långsjö, J., Kallionpää, R. E., Kaisti, K., Radek, L., Johansson, J., Sandman, N., Nyman, M., Scheinin, M., Vahlberg, T., Revonsuo, A., Valli, K., & Scheinin, H. (2021). Foundations of Human Consciousness: Imaging the Twilight Zone. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 41(8), 1769–1778. Link

Pöyhönen, H., Setänen, S., Isaksson, N., Nyman, M. , Nyman, A., Peltola, V., & Lähdesmäki, T. (2021). Neurological and cognitive performance after childhood encephalitis. Frontiers in Pediatrics, 9. Link

2020

Nurminen, J., Velhonoja, J., Heikkinen, J., Happonen, T., Nyman, M., Irjala, H., Soukka, T., Mattila, K., & Hirvonen, J. (2020). Emergency neck MRI: feasibility and diagnostic accuracy in cases of neck infection. Acta Radiologica, 284185120940242. Link

Huhtanen, H., Nyman, M.,Karlsson, A., Hirvonen, J. (2020). Tekoaly radiologiassa (in finnis, AI in Radiology, review). Duodecim, 2020;136(17):1957-64.

Rebelos, E., Hirvonen, J., Bucci, M., Pekkarinen, L., Nyman, M., Hannukainen, J. C., Iozzo, P., Salminen, P., Nummenmaa, L., Ferrannini, E., & Others. (2020). Brain FFA uptake is elevated in morbid obesity, and is irreversible six months after bariatric surgery: a positron emission tomography study. Diabetes, Obesity & Metabolism. https://onlinelibrary.wiley.com/doi/abs/10.1111/dom.13996

Nazari-Farsani, S., Nyman, M., Karjalainen, T., Bucci, M., Isojärvi, J., & Nummenmaa, L. (2020). Automated segmentation of acute stroke lesions using a data-driven anomaly detection on diffusion weighted MRI. Journal of Neuroscience Methods, 333, 10.

2019

Nyman, M.. (2019) Visualization and Quantification of Neurokinin-1 receptors in Human Brain With Positron Emission Tomography. Thesis, Faculty of Medicine, University of Turku. http://urn.fi/URN:ISBN:978-951-29-7704-8

Laurikainen, H., Isotupa, I., Nyman, M., Ilonen T., Nummelin T,, Salokangas, KR., Hietala, J. (2019). Longitudinal brain morphology in anti-NMDA receptor encephalitis: a case report with controls. BMC Psychiatry. 19(1), 145.

Nyman, M., Eskola, O., Kajander, J., Jokinen, R., Penttinen, J., Karjalainen, T., … Hietala, J. (2019). Brain neurokinin-1 receptor availability in never-medicated patients with major depression – A pilot study. Journal of Affective Disorders, 242, 188–194.

2018

Laaksonen, L., Kallioinen, M., Långsjö, J., Laitio, T., Scheinin, A., Scheinin, J., Kaisti, K., Maksimow, A., Kallionpää, R. E., Rajala, V., Johansson, J., Kantonen, O., Nyman, M., Sirén, S., Valli, K., Revonsuo, A., Solin, O., Vahlberg, T., Alkire, M., Scheinin, H (2018). Comparative effects of dexmedetomidine, propofol, sevoflurane, and S-ketamine on regional cerebral glucose metabolism in humans: a positron emission tomography study. British Journal of Anaesthesia.

2016

Jalava-Karvinen, P., Nyman, M., Gardberg, M., Harju, I., Hohenthal, U., & Oksi, J. (2016). Scedosporium apiospermum as a rare cause of central skull base osteomyelitis. Medical Mycology Case Reports, 11, 28–30.

Vanninen, R., Putaala, J., Bode, M., Nyman, M., Pekkola, J., Manninen, H., & Others. (2016). Akuutin aivohalvauspotilaan kuvantaminen valtimotukoksen hoidon suunnittelussa. Duodecim; Laaketieteellinen Aikakauskirja. Vuosikerta. 132 , Nro 21 , Sivut 1973-1982

2008

Huttunen, J., Heinimaa, M., Svirskis, T., Nyman, M., Kajander, J., Forsback, S., … Others. (2008). Striatal dopamine synthesis in first-degree relatives of patients with schizophrenia. Biological Psychiatry, 63(1), 114–117

2007

Koikkalainen, J., Hirvonen, J., Nyman, M., Lötjönen, J., Hietala, J., & Ruotsalainen, U. (2007). Shape variability of the human striatum–Effects of age and gender. NeuroImage, 34(1), 85–93.

Nyman, M. J., Eskola, O., Kajander, J., Vahlberg, T., Sanabria, S., Burns, D., … Hietala, J. (2007). Gender and age affect NK1 receptors in the human brain - a positron emission tomography study with [F-18]SPA-RQ. The International Journal of Neuropsychopharmacology, 10(2), 219–229.

Wallius, E., Nyman, M., Oikonen, V., Hietala, J., & Ruotsalainen, U. (2007). Voxel-based NK1 receptor occupancy measurements with [(18)F]SPA-RQ and positron emission tomography: a procedure for assessing errors from image reconstruction and physiological modeling. Molecular Imaging and Biology, 9(5), 284–294.

2006

Hietanen, J. K., Nummenmaa, L., Nyman, M. J., Parkkola, R., & Hämäläinen, H. (2006). Automatic attention orienting by social and symbolic cues activates different neural networks: an fMRI study. NeuroImage, 33(1), 406–413.

Hietala, J., Nyman, M. J., Eskola, O., Laakso, A., Grönroos, T., Oikonen, V., … Solin, O. (2005). Visualization and quantification of neurokinin-1 (NK1) receptors in the human brain. Molecular Imaging and Biology, 7(4), 262–272.